The NovAliB library of compounds immobilized on the NovAliX chemical microarray SPR screening platform has provided excellent starting points for finding ligands to be used for the purification of biologic proteins by affinity chromatography.

Selectivity can be based upon the recognition of conserved or variable regions of any class of protein.  This is a unique means to address any challenging downstream purification, or requirement for selective enrichment or depletion of proteins.

The initial screening hits can be optimized by combining skills of the synthetic chemists to deliver novel ligands that meet all essential requirements for selectivity, yield, productivity, stability and cost.