Individual step optimization

Minimizing costs maximizing productivity

Through the judicious combination of expert insight and the investigation of multiple conditions in parallel NovAliX can move very fast to get the best performance out of any process.

NovAliX chemists are schooled and skilled in practical process considerations, principally debottlenecking and the anticipation of the scale-up issues. The result, processes that are scalable, robust, productive and safe.

Success is the achieved through effective teamwork combined with personal inspiration and the serendipity that arises from shear trial and error perseverance. Judicious advantage is taken of smart tools such as Design of Experiments, Process Analytical Technologies and automated high-productivity platforms.

Features and benefits

Optimizing a step employs 1-2 synthetic chemists plus analytical support. All studies are conducted within a smooth and well-coordinated workflow:

Study Associated tool or methodology Included
Overall step efficiency (yield, selectivity, volume-time productivity, cost of raw materials). Based on collective experience & in-house technologies.  
Identification of critical parameters & optimization (broad screening followed by fine-tuning of reaction parameters) Design of Experiment, Process Analytical Technologies  
Optimization or work-up; isolation & purification (elimination of chromatography) Crystallization condition screening platform  
Robustness assessment, in process configured reactors HEL fully automated platform of 50 mL reactors Optional
Preliminary safety studies (thermal hazard evaluation of product intermediates/reaction mixtures & prediction of large-scale effects) DSC, automated reactors with Pt100 internal probes, Stoessel diagram Optional
Scalability Up to 10 L reactor, process expertise  
Synthesis of representative batches  
Biweekly reporting E-mail & WebEx  
Final report Critical details & full experimental procedures