Minimizing costs maximizing productivity
Through the judicious combination of expert insight and the investigation of multiple conditions in parallel NovAliX can move very fast to get the best performance out of any process.
NovAliX chemists are schooled and skilled in practical process considerations, principally debottlenecking and the anticipation of the scale-up issues. The result, processes that are scalable, robust, productive and safe.
Success is the achieved through effective teamwork combined with personal inspiration and the serendipity that arises from shear trial and error perseverance. Judicious advantage is taken of smart tools such as Design of Experiments, Process Analytical Technologies and automated high-productivity platforms.
Optimizing a step employs 1-2 synthetic chemists plus analytical support. All studies are conducted within a smooth and well-coordinated workflow:
|Study||Associated tool or methodology||Included|
|Overall step efficiency (yield, selectivity, volume-time productivity, cost of raw materials).||Based on collective experience & in-house technologies.|
|Identification of critical parameters & optimization (broad screening followed by fine-tuning of reaction parameters)||Design of Experiment, Process Analytical Technologies|
|Optimization or work-up; isolation & purification (elimination of chromatography)||Crystallization condition screening platform|
|Robustness assessment, in process configured reactors||HEL fully automated platform of 50 mL reactors||Optional|
|Preliminary safety studies (thermal hazard evaluation of product intermediates/reaction mixtures & prediction of large-scale effects)||DSC, automated reactors with Pt100 internal probes, Stoessel diagram||Optional|
|Scalability||Up to 10 L reactor, process expertise|
|Synthesis of representative batches|
|Biweekly reporting||E-mail & WebEx|
|Final report||Critical details & full experimental procedures|