NovAliX often evaluates several routes simultaneously to rapidly find the best and eliminate the rest.
Testing the feasibility of novel routes and the parallel screening of conditions for key reactions requires of the order 1 to 3 months.
To achieve this productivity consistently we have established a robust work-system, combining the use of internally developed screening platforms with a wide range of capabilities. Key analytical tools deliver essential information rapidly to the synthetic chemists.
In this critical process research stage, any new concerns or potential problems will be identified, addressed and fully reported. NovAliX’ proprietary Chemical Data Management tool provides unprecedented solutions to many chemical questions. NovAliX chemists have established a strong reputation as chemical solution providers.
Within 1 to 3 months a team of 2/3 chemists with analytical support will scout 2 to 5 routes in parallel. Studies are performed within a smooth and well-coordinated workflow:
|Study||Associated tool or methodology||Included|
|Evaluation of key reaction feasibility||– Quantitative analytical methods
– Multi-block reactors with 48 positions, at
-78 °C to 180 °C & up to 15 bar
– Design of Experiments (Design Expert software)
– Chemical Data management
|Understanding of key reaction scope|
|Identification of critical process parameters|
|Large screening of conditions for critical parameters|
|Evaluation of route feasibility|
|Synthesis of representative batches (1-5g)|
|Refinement of cost evaluation||Cost evaluation program||Optional|
|Biweekly reporting||E-mails & webexs|
|Final report||Critical comparisons & full experimental details|