Process research and route scouting

Synthesis lock

NovAliX often evaluates several routes simultaneously to rapidly find the best and eliminate the rest.

Testing the feasibility of novel routes and the parallel screening of conditions for key reactions requires of the order 1 to 3 months.

To achieve this productivity consistently we have established a robust work-system, combining the use of internally developed screening platforms with a wide range of capabilities. Key analytical tools deliver essential information rapidly to the synthetic chemists.

In this critical process research stage, any new concerns or potential problems will be identified, addressed and fully reported. NovAliX’ proprietary Chemical Data Management tool provides unprecedented solutions to many chemical questions. NovAliX chemists have established a strong reputation as chemical solution providers.

Features and benefits

Within 1 to 3 months a team of 2/3 chemists with analytical support will scout 2 to 5 routes in parallel. Studies are performed within a smooth and well-coordinated workflow:

Study Associated tool or methodology Included
Evaluation of key reaction feasibility – Quantitative analytical methods
– Multi-block reactors with 48 positions, at
-78 °C to 180 °C & up to 15 bar
– Design of Experiments (Design Expert software)
– Chemical Data management
 
Understanding of key reaction scope  
Identification of critical process parameters  
Large screening of conditions for critical parameters  
Evaluation of route feasibility  
Synthesis of representative batches (1-5g)  
Refinement of cost evaluation Cost evaluation program Optional
Biweekly reporting E-mails & webexs  
Final report Critical comparisons & full experimental details