All the Publications

July 13, 2018

Biophysics in drug discovery: impact, challenges and opportunities.

Jean-Paul Renaud, Chun-wa Chung, Helena Danielson, Ursula Egner, Michael Hennig, Rod Hubbard, Herbert Nar

Nature Reviews Drug Discovery 2016 Oct;15(10):679-98. doi: 10.1038/nrd.2016.123. Epub 2016 Aug 12.

March 27, 2018

Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

Gaspar L, Coron RP, KongThoo Lin P, Costa DM, Perez-Cabezas B, Tavares J, Roura-Ferrer M, Ramos I, Ronin C, Major LL, Ciesielski F, Pemberton IK, MacDougall J, Ciapetti P, Smith TK, Cordeiro-da-Silva A.
PLoS Negl Trop Dis. 2018 Jan 22;12(1):e0006180. doi: 10.1371/journal.pntd.0006180. eCollection 2018 Jan.
March 27, 2018

The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.

Ronin C, Costa DM, Tavares J, Faria J, Ciesielski F, Ciapetti P, Smith TK, MacDougall J, Cordeiro-da-Silva A, Pemberton IK.
PLoS One. 2018 Mar 15;13(3):e0193602. doi: 10.1371/journal.pone.0193602. eCollection 2018.
June 15, 2017

Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3

Cédric Atmanene, Céline Ronin, Stéphane Téléchéa, François-Moana Gautier, Florence Djedaïni-Pilard, Fabrice Ciesielski, Valérie Vivat, Cyrille Grandjean

Biochemical and Biophysical Research Communications 489 (2017) 281-286. https://doi.org/10.1016/j.bbrc.2017.05.150 

 

 

March 8, 2017

Discovery of phenoxyindazoles and phenylthioindazoles as ROR gamma inverse agonists

Gilles Ouvry, Claire Bouix-Peter, Fabrice Ciesielski, Laurent Chantalat, Olivier Christin, Catherine Comino, Denis Duvert, Christophe Feret, Craig S. Harris, Laurent Lamy, Anne-Pascale Luzy, Branislav Musicki, Danielle Orfila, Jonathan Pascau, Véronique Parnet, Agnès Perrin, Romain Pierre, Gaëlle Polge, Catherine Raffin, Yves Rival, Nathalie Taquet, Etienne Thoreau, Laurent F. Hennequin

Bioorganic & Medicinal Chemistry Letters 26 (2016) 5802–5808; http://dx.doi.org/10.1016/j.bmcl.2016.10.023

October 26, 2015

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St. George-Hyslop, Eva M. Mandelkow, Christopher M. Dobson, Lisa McConlogue, Eckhard Mandelkow and Gergely Toth.

Current Alzheimer Research, 2015, 12(9), 814-828

September 9, 2015

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W.

Nat Commun. 2015 Sep 3;6:8089.

September 9, 2015

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists.

Schiebel J, Radeva N, Köster H, Metz A, Krotzky T, Kuhnert M, Diederich WE, Heine A, Neumann L, Atmanene C, Roecklin D, Vivat-Hannah V, Renaud JP, Meinecke R, Schlinck N, Sitte A, Popp F, Zeeb M, Klebe G.

ChemMedChem. 2015 Sep;10(9):1511-21

November 26, 2014

Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634.

Menet CJ, Fletcher SR, Van Lommen G, Geney R, Blanc J, Smits K, Jouannigot N, Deprez P, van der Aar EM, Clement-Lacroix P, Lepescheux L, Galien R, Vayssiere B, Nelles L, Christophe T, Brys R, Uhring M, Ciesielski F, Van Rompaey L.

J Med Chem. 2014 Nov 26;57(22):9323-42. doi: 10.1021/jm501262q. Epub 2014 Nov 17.