All the Publications

December 16, 2019

SEM-STEM optimization of sample preparation for structural analysis by Cryo-EM

Kateřina Němcová, Mircea-Ioan Iacovache,a Wen-Ti Liu,b Diane van Rossum,c Keriya Mam,c Petr Wandrol,d Miloš Hovorka,d and Jaroslav Starek,d Hervé-William Rémigy,c*

a Microscopic Anatomy and Structural Biology, University of Bern, Switzerland
b NovAliX, Illkirch, France
c Thermofisher Scientific, Eindhoven, Netherlands
d Thermofisher Scientific, Brno, Czech Republic * 

Whitepaper on American Pharmaceutical Review

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July 5, 2019

Plant natural fragments, an innovative approach for drug discovery

David B.; Grondin A.; Schambel P.; Vitorino M.; Zeyer D. Phytochemistry Rev. 10.1007/s11101-019-09612-4

July 13, 2018

Biophysics in drug discovery: impact, challenges and opportunities.

Jean-Paul Renaud, Chun-wa Chung, Helena Danielson, Ursula Egner, Michael Hennig, Rod Hubbard, Herbert Nar

Nature Reviews Drug Discovery 2016 Oct;15(10):679-98. doi: 10.1038/nrd.2016.123. Epub 2016 Aug 12.

March 27, 2018

Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

Gaspar L, Coron RP, KongThoo Lin P, Costa DM, Perez-Cabezas B, Tavares J, Roura-Ferrer M, Ramos I, Ronin C, Major LL, Ciesielski F, Pemberton IK, MacDougall J, Ciapetti P, Smith TK, Cordeiro-da-Silva A.
PLoS Negl Trop Dis. 2018 Jan 22;12(1):e0006180. doi: 10.1371/journal.pntd.0006180. eCollection 2018 Jan.
March 27, 2018

The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.

Ronin C, Costa DM, Tavares J, Faria J, Ciesielski F, Ciapetti P, Smith TK, MacDougall J, Cordeiro-da-Silva A, Pemberton IK.
PLoS One. 2018 Mar 15;13(3):e0193602. doi: 10.1371/journal.pone.0193602. eCollection 2018.
June 15, 2017

Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3

Cédric Atmanene, Céline Ronin, Stéphane Téléchéa, François-Moana Gautier, Florence Djedaïni-Pilard, Fabrice Ciesielski, Valérie Vivat, Cyrille Grandjean

Biochemical and Biophysical Research Communications 489 (2017) 281-286. https://doi.org/10.1016/j.bbrc.2017.05.150 

 

 

March 8, 2017

Discovery of phenoxyindazoles and phenylthioindazoles as ROR gamma inverse agonists

Gilles Ouvry, Claire Bouix-Peter, Fabrice Ciesielski, Laurent Chantalat, Olivier Christin, Catherine Comino, Denis Duvert, Christophe Feret, Craig S. Harris, Laurent Lamy, Anne-Pascale Luzy, Branislav Musicki, Danielle Orfila, Jonathan Pascau, Véronique Parnet, Agnès Perrin, Romain Pierre, Gaëlle Polge, Catherine Raffin, Yves Rival, Nathalie Taquet, Etienne Thoreau, Laurent F. Hennequin

Bioorganic & Medicinal Chemistry Letters 26 (2016) 5802–5808; http://dx.doi.org/10.1016/j.bmcl.2016.10.023

October 26, 2015

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St. George-Hyslop, Eva M. Mandelkow, Christopher M. Dobson, Lisa McConlogue, Eckhard Mandelkow and Gergely Toth.

Current Alzheimer Research, 2015, 12(9), 814-828

September 9, 2015

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W.

Nat Commun. 2015 Sep 3;6:8089.