All the Publications

May 29, 2020

Preparation of Recombinant Membrane Proteins from Pichia pastoris for Molecular Investigations

Lucile Guyot, Lucie Hartmann, Sarah Mohammed-Bouteben, Lydia Caro, Renaud Wagner

Current Protocols in Protein Science, 100, e104. doi: 10.1002/cpps.104

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January 23, 2020

“Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of Alpha-Synuclein Protect Against Diverse Alpha-Synuclein Mediated Dysfunctions”

Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F. Jobling, Shyra J. Gardai, Carlos W. Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C. Tabios, Mitali A. Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P. Anderson, Balazs Szoke, Wherly Hoffman, John Christodoulou, Ted Yednock, David A. Agard, Dale Schenk & Lisa McConlogue.

Scientific Reports volume 9, Article number: 16947 (2019)

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December 16, 2019

SEM-STEM optimization of sample preparation for structural analysis by Cryo-EM

Kateřina Němcová, Mircea-Ioan Iacovache,a Wen-Ti Liu,b Diane van Rossum,c Keriya Mam,c Petr Wandrol,d Miloš Hovorka,d and Jaroslav Starek,d Hervé-William Rémigy,c*

a Microscopic Anatomy and Structural Biology, University of Bern, Switzerland
b NovAliX, Illkirch, France
c Thermofisher Scientific, Eindhoven, Netherlands
d Thermofisher Scientific, Brno, Czech Republic * 

Whitepaper on American Pharmaceutical Review

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July 5, 2019

Plant natural fragments, an innovative approach for drug discovery

David B.; Grondin A.; Schambel P.; Vitorino M.; Zeyer D. Phytochemistry Rev. 10.1007/s11101-019-09612-4

July 13, 2018

Biophysics in drug discovery: impact, challenges and opportunities.

Jean-Paul Renaud, Chun-wa Chung, Helena Danielson, Ursula Egner, Michael Hennig, Rod Hubbard, Herbert Nar

Nature Reviews Drug Discovery 2016 Oct;15(10):679-98. doi: 10.1038/nrd.2016.123. Epub 2016 Aug 12.

March 27, 2018

Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

Gaspar L, Coron RP, KongThoo Lin P, Costa DM, Perez-Cabezas B, Tavares J, Roura-Ferrer M, Ramos I, Ronin C, Major LL, Ciesielski F, Pemberton IK, MacDougall J, Ciapetti P, Smith TK, Cordeiro-da-Silva A.
PLoS Negl Trop Dis. 2018 Jan 22;12(1):e0006180. doi: 10.1371/journal.pntd.0006180. eCollection 2018 Jan.
March 27, 2018

The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.

Ronin C, Costa DM, Tavares J, Faria J, Ciesielski F, Ciapetti P, Smith TK, MacDougall J, Cordeiro-da-Silva A, Pemberton IK.
PLoS One. 2018 Mar 15;13(3):e0193602. doi: 10.1371/journal.pone.0193602. eCollection 2018.
June 15, 2017

Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3

Cédric Atmanene, Céline Ronin, Stéphane Téléchéa, François-Moana Gautier, Florence Djedaïni-Pilard, Fabrice Ciesielski, Valérie Vivat, Cyrille Grandjean

Biochemical and Biophysical Research Communications 489 (2017) 281-286. https://doi.org/10.1016/j.bbrc.2017.05.150 

 

 

March 8, 2017

Discovery of phenoxyindazoles and phenylthioindazoles as ROR gamma inverse agonists

Gilles Ouvry, Claire Bouix-Peter, Fabrice Ciesielski, Laurent Chantalat, Olivier Christin, Catherine Comino, Denis Duvert, Christophe Feret, Craig S. Harris, Laurent Lamy, Anne-Pascale Luzy, Branislav Musicki, Danielle Orfila, Jonathan Pascau, Véronique Parnet, Agnès Perrin, Romain Pierre, Gaëlle Polge, Catherine Raffin, Yves Rival, Nathalie Taquet, Etienne Thoreau, Laurent F. Hennequin

Bioorganic & Medicinal Chemistry Letters 26 (2016) 5802–5808; http://dx.doi.org/10.1016/j.bmcl.2016.10.023