X-ray crystallography – Protein and co-crystal structure determination
Access to accurate high-resolution molecular structures is essential for the understanding of biological processes and to support drug discovery programs.
X-ray crystallography is the gold standard for the structural determination of protein complexes with other proteins, nucleic acids and small organic ligands.
X-ray crystallography can reliably provide the answer to many structure related questions, from global folds to atomic details of bonding, without any size limitation of the complex. Precise interactions between protein and ligand can be visualized with atomic resolution giving profound insight into the mechanism of molecular recognition, an approach that has revolutionized the rational design of new drugs.
NovAliX scientists are internationally recognized and valued by clients both for their state of the art problem solving skills as well as the efficient delivery of routine services.
Structures are determined for de novo targets and protein-ligand complexes. These are available as a stand-alone service or as part of a drug discovery package.